The Science of our Ingredients
Melatonin:
Five clinical studies showed positive effects of a topical melatonin solution in the treatment of AGA in men and women while showing good tolerability: (1) Pharmacodynamics under once-daily topical application in the evening . An observational study involving 30 men and women showed a significant reduction in the degree of severity of alopecia after 30 and 90 days (P < 0.001) based on questionnaires completed by investigators and patients. (3) Using a digital software-supported epiluminescence technique (TrichoScan) in 35 men with AGA, after 3 and 6 months in 54.8% to 58.1% of the patients a significant increase of hair density of 29% and 41%, respectively was measured (M0: 123/cm2; M3: 159/cm2; M6: 173/cm2;) (P < 0,001). (4) In 60 men and women with hair loss, a significant reduction in hair loss was observed in women. In a large, 3-month, multi-center study with more than 1800 volunteers at 200 centers, the percentage of patients with a 2- to 3-fold positive hair-pull test decreased from 61.6% to 7.8%, while the percentage of patients with a negative hair-pull test increased from 12.2.% to 61.5% (P < 0.001). In addition, a decrease in seborrhea and seborrheic dermatitis of the scalp was observed.
Saw Palmetto
Standardized to contain 45% Fatty Acids. Five randomized clinical trials (RCTs) and 2 prospective cohort studies demonstrated positive effects of topical and oral supplements containing SP (100–320 mg) among patients. We were unable to find a study with a listed topical percent formula, only oral dosage. We would like to seek advisement if there is a way to convert an oral dosage of say 300mg to a topical so that each each application of 2ml would be equivalent to the oral dosage or if you have a recommendation for common dosage for topical applications.
Caffeine
Topical caffeine has gained popularity as a potential treatment for hair loss due to its various benefits and the scientific evidence supporting its efficacy. Caffeine, when applied topically to the scalp, can stimulate hair follicles and promote hair growth. It works by blocking the effects of dihydrotestosterone (DHT), a hormone responsible for shrinking hair follicles and leading to hair loss. Additionally, caffeine enhances blood circulation in the scalp, delivering vital nutrients and oxygen to the hair follicles, which can improve their health and function. Several studies have supported the use of topical caffeine for hair loss, demonstrating its potential as a promising and natural solution.
Rosemary Oil
Rosemary oil has been recognized for its potential benefits in promoting hair growth and combating hair loss, supported by scientific research. Rosemary oil contains various compounds, such as rosmarinic acid, carnosic acid, and ursolic acid, which possess anti-inflammatory and antioxidant properties. These properties help reduce inflammation in the scalp and protect hair follicles from damage caused by free radicals. Additionally, rosemary oil has been found to increase blood circulation in the scalp, facilitating the delivery of nutrients and oxygen to the hair follicles. Studies have indicated that rosemary oil can enhance hair growth and improve hair thickness. However, further research is still needed to fully understand the mechanisms and long-term effects of rosemary oil on hair growth.
Peppermint Oil
A 2015 study compared rosemary oil to minoxidil, a popular hair regrowth treatment. People with DHT-related hair loss received either rosemary oil or minoxidil for 6 months. By 6 months, both groups saw significant increases in hair growth. The patients applied 1 ml of rosemary oil lotion (3.7 mg/ml 1,8-cineole) We would like to replicate this topical application dosage.
Green Tea Decaffeinated Extract
A study conducted by Phytomedicine (2007) measured the effectiveness of EGCG green tea hair growth in a test tube (in-vitro) and a living organism (in-vivo). The experiment determined the potential benefits of EGCG hair loss treatment on human dermal papilla cells (DPCs) in-vitro and in-vivo (2). Dermal papilla cells regulate hair follicle growth and development. A study has shown that EGCG found in green tea is a natural remedy that slows down the production of 5 alpha-reductase (4)
The investigation found green tea extract hair growth was noticeable in both in-vivo and in-vitro experimentation. The study concluded that EGCG promotes hair growth through its anti-apoptotic (programmed cell death) effect on dermal papilla cells.
Skinmed (2012) published a review of twenty studies that observed the use of green tea in dermatology in terms of hair growth. Among the studies were in-vitro (in a test tube) and in-vivo (in a living organism) experiments that analyzed the effects that green tea extracts have on hair (1). In the end, scientists concluded that green tea can be effective in treating androgenetic alopecia.
D-Panthenol
"Dexpanthenol (D-panthenol) is a precursor of vitamin B5 (pantothenic acid) and is widely used for dietary supplements and topical applications. D-panthenol has long been used in hair care products for the purpose of anti-hair loss, its effects and the underlying mechanisms, however, were barely reported. The effects of D-panthenol on human hair follicle cells, including dermal papilla cells (hDPCs) and outer root sheath cells (hORSCs), were investigated. D-panthenol enhanced the cell viability, increasing the cellular proliferation marker Ki67 in cultured hDPCs. The markers for apoptosis (Caspase3/9) and cell senescence (p21/p16), reported to be expressed in aged or resting phase follicles, were significantly reduced by D-panthenol. Anagen-inducing factors (ALP; β-catenin; versican), which trigger or elongate the anagen phase, were stimulated by D-panthenol. On the other hand, D-panthenol reduced TGF-β1 expressions in both mRNA and protein levels. The expression of VEGF, which is important for peripheral blood vessel activation; was up-regulated by D-panthenol treatment. In cultured hORSCs, cell proliferation and viability were enhanced, while the mRNA expression of cell senescence markers (p21/p16) was significantly down-regulated. The expressions of both VEGF and its receptor (VEGFR) were up-regulated by D-panthenol. In conclusion, our data suggest that the hair growth stimulating activity of D-panthenol was exerted by increasing the cell viability, suppressing the apoptotic markers, and elongating the anagen phase in hair follicles."
Sources:
https://pubmed.ncbi.nlm.nih.gov/17214716
https://pubmed.ncbi.nlm.nih.gov/24836650/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681103/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706486/
https://pubmed.ncbi.nlm.nih.gov/25842469/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289931/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576011/pdf/jnma00189-0119.pdf
https://pubmed.ncbi.nlm.nih.gov/23346663/
https://pubmed.ncbi.nlm.nih.gov/17092697/
https://pubmed.ncbi.nlm.nih.gov/11931850/
https://pubmed.ncbi.nlm.nih.gov/34698060/
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